Cannabis and Schizophrenia

The 6 March 2018 didactic addressed the relationship between marijuana use and schizophrenia. Download the PowerPoint file.

The evidence linking cannabis use to schizophrenia is compelling.

Cannabis use affects brain maturation and affects the signaling of both dopamine and glutamate – two neurotransmitters with known relevance to schizophrenia. There is clear evidence of a dose-response relationship. Higher cumulative exposure to cannabis in early life translates into higher risk of schizophrenia in later life. Mendelian randomization, a genetic analysis strategy that eliminates the influence of confounding variables, suggests that the relationship between cannabis use and schizophrenia is causative – not coincidental.